The election for this seat was for a six-year term.
Republicans won their 20th consecutive seat to the office of Railroad / Railroad and Warehouse Commissioner. This election also marked the largest victory margin in a race for Railroad or Railroad and Warehouse Commissioner in Minnesota history and one of only two elections decided by 30+ points (1881, 30.3 points).
Commissioner Jacobson was reelected to a third term.
MacKenzie was a resident of St. Paul and Nonpartisan League organizer.
Robinson was a resident of Minneapolis and railroad auditor.
May was a resident of Minneapolis and Socialist endorsed candidate for Minneapolis 6th Ward Alderman in 1921. May was nominated by petition.