Senator Nelson was reelected to a fifth term. This election is one of four in Minnesota history without a Democratic candidate (1928, 1936, 1936-special). The Democratic state executive committee unanimously endorsed Nelson. Nelson died in office on April 28, 1923.
Calderwood was a resident of Minneapolis, state chair of the Prohibition Party, Prohibition nominee for HD 30 in 1894, for HD 39 in 1904, 1906, 1908, and 1910, for the at-large U.S. House seat in 1912, for Governor in 1914, and for the U.S. Senate in 1916. He was also a Farmer-Labor candidate for Lieutenant Governor in 1924.